We wish to recruit a talented postdoctoral research fellow to undertake an ambitious research project investigating how maternal bodyweight affects early embryo development processes in ways that can influence lifelong health. The project will also explore the possibility of restoring metabolic disruption in embryos originating from women whom are overweight and obese.
Significant research has established that events occurring around the time of conception can induce biochemical, metabolic and genomic responses in the early embryo. These changes appear to persist throughout pregnancy and offer a possible mechanism explaining why prenatal exposure may influence postnatal health. The Hull York Medical School, University of Hull, was recently awarded a prestigious grant to describe in unparalleled detail the impact of being overweight or obese on human embryo development, and then to explore strategies to correct the predicted responses. This exciting project is technically challenging and offers an opportunity to provide insight into the processes of early development. Working closely with colleagues at the University of Manchester and in a local clinical IVF facility, the successful applicant will use a range of experimental methods to examine single cell gene expression and metabolic biochemistry of human embryos that are no longer required for clinical use.
We encourage you to apply if you have experience of working with mammalian preimplantation embryos, ideally human, and have an interest in how energy metabolism drives key molecular processes in the first stages of embryo development. Experience of working within HFEA regulatory frameworks would be a distinct advantage.
To discuss this role informally, please contact Dr Roger Sturmey, 01482 466422, firstname.lastname@example.org
Interviews are anticipated to be held week commencing 10 June 2019 with an anticipated start date as soon as possible thereafter.